Strand offers compound libraries focused on specific targets:
- Novel machine learning-based compound activity model
- Pharmacoffold technology to increase hit rate
- Pre-Filtered and annotated for human PK and cardio-toxicity
- Screened for IP potential
Highlights of Strand's methodology
- Use state-of-the-art in silico techniques for library design
- A robust QSAR classification model for screening compounds effectively
- Intelligent perception of necessary & sufficient SAR across ligands against particular targets
- Novel way of defining the 'cores' of the compounds around which library is built.
- Judicious bio-isosteric replacement ensuring retainment of binding and activity
- Addition of 'R groups' done intelligently ensuring compliance of the whole molecule to both
Pharmacophore and the QSAR
- Optional pharmacokinetic filtering using in-house tool going beyond Lipinski's rule of five
- Ability to handle stereospecific targets and to deliver stereoselective ligands
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